Highly Significant Impact of HLA-DRB3 and -DRB4 Matching on Different Unrelated allo-HSCT Outcomes: New Perspectives in the Unrelated Donor Selection
نویسندگان
چکیده
منابع مشابه
The impact of HLA matching on unrelated donor hematopoietic stem cell transplantation in Korean children
BACKGROUND The impact of HLA matching on outcomes of unrelated donor (URD) hematopoietic stem cell transplantation (HSCT) varies in different racial or ethnic groups. Since little is known about the impact of such matching on URD HSCT in Korean children, we analyzed this issue. METHODS We analyzed the outcomes of 142 patients who underwent URD HSCT at 4 Korean medical centers. All patient don...
متن کاملTRANSPLANTATION HLA-DPB1 matching status has significant implications for recipients of unrelated donor stem cell transplants
Studies in unrelated donor (UD) hematopoietic stem cell transplantations (HSCT) show an effect of the matching status of HLA-DPB1 on complications. We analyzed 423 UD-HSCT pairs. Most protocols included T-cell depletion (TCD). All pairs had high-resolution tissue typing performed for 6 HLA loci. Two hundred eightytwo pairs were matched at 10 of 10 alleles (29% were DPB1 matched). In 141 HLAmism...
متن کاملHLA-DPB1 matching status has significant implications for recipients of unrelated donor stem cell transplants.
Studies in unrelated donor (UD) hematopoietic stem cell transplantations (HSCT) show an effect of the matching status of HLA-DPB1 on complications. We analyzed 423 UD-HSCT pairs. Most protocols included T-cell depletion (TCD). All pairs had high-resolution tissue typing performed for 6 HLA loci. Two hundred eighty-two pairs were matched at 10 of 10 alleles (29% were DPB1 matched). In 141 HLA-mi...
متن کاملThe Predictive Value of HLA-DR Matching and Cytokine Gene Polymorphisms in Renal Allograft Acute Rejection: A Living-unrelated Donor (LURD) Study
Background: In addition to Human Leukocyte Antigens (HLA) compatibility, gene polymorphisms in cytokines might also be important in the quality of allogeneic immune response. Objective: To evaluate the influence of HLA-DR matching and a number of cytokine gene polymorphisms on acute rejection after living-unrelated donor (LURD) kidney transplantation. Methods: A total of 42 renal transplants pe...
متن کاملHigh-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation.
The relative importance of various human leukocyte antigen (HLA) loci and the resolution level at which they are matched has not been fully defined for unrelated donor transplantation. To address this question, National Marrow Donor Program data from 3857 transplantations performed from 1988 to 2003 in the United States were analyzed. Patient-donor pairs were fully typed for HLA-A, -B, -C, -DRB...
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ژورنال
عنوان ژورنال: Biology of Blood and Marrow Transplantation
سال: 2012
ISSN: 1083-8791
DOI: 10.1016/j.bbmt.2011.12.537